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Although these classic AD symptoms are attributable to posterior cerebral dysfunction, AD dementia usually causes some frontal (executive) dysfunction even early in the disease course.

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Subjects were excluded if: 1) a neurodegenerative disorder other than AD was present, 2) there was any serious and clinically significant illness, 3) if there was a history of previous cerebral infarction, or 4) acetylcholinesterase inhibitors were used within 3 months before inclusion.

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When examining the number needed to treat, ranging from four to 12 in these studies, the authors reported that for every nine to 25 subjects helped in these trials there would possibly be one death.

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The cholinesterase will increase the rate at which acetylcholine is broken down, by breaking, as the name suggests, the ester bond, and producing choline and acetic acid.

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Scientists have some theories about mechanisms that may lead to different forms of dementias, but more research is needed to better understand if and how these mechanisms contribute to the development of dementia.

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