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Only the site pharmacist, pharmacokinetic assay laboratory, coleaders of the coordinating center, and data and safety monitoring board were aware of the study-group assignments.

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Effect of rosuvastatin on concentrations of plasma lipids, urine and plasma oxidative stress markers, and plasma high-sensitivity C-reactive protein in hypercholesterolemic patients with and without type 2 diabetes mellitus: A 12-week, open-label, pilot study.

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Answers B, C, and D may be needed at a later time but are not the most important actions to take first.

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Statin Medications and Development and Progression of Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms.

Graham urged closer surveillance of the drug to nail down a suspected link between it and kidney failures.

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Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism.

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In other words, the JUPITER study was stopped at two years whereas the ASCAPS study stopped after 5 years, and the JUPITER data must be carried forward presumptively to derive a risk adjustment for exposure to the drug.

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Other aspects that may account for differences in outcomes between women and men are related to vascular biological factors such as a smaller atheroma burden and slower progression in women, a smaller vessel size, less collateral flow, lower coronary flow reserve, more vascular stiffness, differences in remodelling, and functional differences of smooth muscle cells in the vessel wall.

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The evidence for treatment, especially with cholesterol-lowering drugs, is much weaker for people who have not yet had the cardiovascular disease described above, known as primary prevention.

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Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS).

This decision reaffirms the right of generic drug manufacturers to submit ANDA applications for drugs that are covered only by methods of treatment so long as the ANDA application is not directed to those patented methods.

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Schering-Plough, Sanofi-Aventis, Isis, Dade Behring, and Vascular Biogenics; and is listed as a coinventor on patents held by Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease, including the use of high-sensitivity C-reactive protein in the evaluation of patients' risk of cardiovascular disease.

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