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How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease.

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When the data were analyzed according to the intention-to-treat principle, because such analysis includes subjects who withdrew and noncompliant subjects, there was an apparent reduction in the observed difference in LDL cholesterol levels between treatment groups over time.

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Both drugs significantly reduce pain compared with placebo but celecoxib appears to have a slower onset of action.

Effects of atorvastatin and ezetimibe on endothelial function in dyslipidemic patients with chronic kidney disease.

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Intensive lipid lowering therapy with titrated rosuvastatin yields greater atherosclerotic aortic plaque regression: Serial magnetic resonance imaging observations from RAPID study.

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Viberzi should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

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Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy.

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We hypothesized that rosuvastatin therapy would improve clinical outcomes in critically ill patients with sepsis-associated ARDS.

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Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor β1-mediated activation of intestinal fibroblasts.

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Antioxidant Effects of Statins in Patients with Atherosclerotic Cerebrovascular Disease.

Translational atherosclerosis research: From experimental models to coronary artery disease in humans.

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CCPA 1935) the court held that the patentee could not use reissue to obtain broader claims to cover “improvements in the art which have occurred since the date of issuance of the original patent” and were “not intended to be incorporated in the original application.

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Statins, fibrates, nicotinic acid, cholesterol absorption inhibitors, anion-exchange resins, omega-3 fatty acids: which drugs for which patients?

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Based on the limited evidence about the potential drug interactions, it is essential that you talk with your doctor if you are taking medication and are considering drinking pomegranate juice.

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Risk of thrombocytopenia, which may be more severe than prior to therapy, after discontinuance of eltrombopag.

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However, safety and efficacy have not been established in children younger than 8 years of age.

Only the site pharmacist, pharmacokinetic assay laboratory, coleaders of the coordinating center, and data and safety monitoring board were aware of the study-group assignments.

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Effect of rosuvastatin on concentrations of plasma lipids, urine and plasma oxidative stress markers, and plasma high-sensitivity C-reactive protein in hypercholesterolemic patients with and without type 2 diabetes mellitus: A 12-week, open-label, pilot study.

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The present multicenter, 6-week, randomized, double-blind, parallel-group, clinical trial evaluated the safety and efficacy of ezetimibe (10 mg) added to stable rosuvastatin therapy versus up-titration of rosuvastatin from 5 to 10 mg or from 10 to 20 mg.

Rosuvastatin for Reduction of Myocardial Damage during Coronary Angioplasty - the Remedy Trial.

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The role of Pgp in rosuvastatin efflux was assessed using MDR1-MDCK cells, a cell line widely used to identify Pgp substrates.

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Possible side effects of drugs in elderly patients with chronic obstructive pulmonary disease and comorbidity.

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Carbamazepine: May need dose adjustment for APTIOM or carbamazepine.

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Answers B, C, and D may be needed at a later time but are not the most important actions to take first.


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The primary endpoint was hospitalization for acute kidney injury, defined using a validated algorithm (diagnosis code for acute kidney injury in any of the following listed diagnoses: ICD-9 584, 584.

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Statin Medications and Development and Progression of Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms.

Graham urged closer surveillance of the drug to nail down a suspected link between it and kidney failures.

Discovery of major and minor gene variants is providing important information about relationships with lipoprotein abnormalities.

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Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism.

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New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process.

In other words, the JUPITER study was stopped at two years whereas the ASCAPS study stopped after 5 years, and the JUPITER data must be carried forward presumptively to derive a risk adjustment for exposure to the drug.

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Is High-Intensity Statin Therapy Associated With Lower Statin Adherence Compared With Low- to Moderate-Intensity Statin Therapy?

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Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.

This work and any views expressed within it are solely those of the authors and not of any affiliated bodies or organisations.

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Other aspects that may account for differences in outcomes between women and men are related to vascular biological factors such as a smaller atheroma burden and slower progression in women, a smaller vessel size, less collateral flow, lower coronary flow reserve, more vascular stiffness, differences in remodelling, and functional differences of smooth muscle cells in the vessel wall.

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The evidence for treatment, especially with cholesterol-lowering drugs, is much weaker for people who have not yet had the cardiovascular disease described above, known as primary prevention.

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Results of the 4D study: ten years of follow-up?

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Effect of n-3 polyunsaturated fatty acids and rosuvastatin in patients with heart failure: results of the GISSI-HF trial.

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Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS).

This decision reaffirms the right of generic drug manufacturers to submit ANDA applications for drugs that are covered only by methods of treatment so long as the ANDA application is not directed to those patented methods.

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Schering-Plough, Sanofi-Aventis, Isis, Dade Behring, and Vascular Biogenics; and is listed as a coinventor on patents held by Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease, including the use of high-sensitivity C-reactive protein in the evaluation of patients' risk of cardiovascular disease.

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Nevertheless, the newer aspects of the draft guidance seems to have already been implemented at the FDA, as Merck Research Laboratories has already received several specific recommendations from FDA reviewers that referenced the latest draft guidance.

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Statins for the prevention and treatment of acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis.

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Histamine-blocking agents such as Zantac should be taken 30 minutes before meals, so answer A is incorrect.

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