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One multicentre trial in the UK and US compared cognitive function in 309 children born to mothers with epilepsy; it found sodium valproate use was associated with an IQ level eight points lower in children born to mothers taking sodium valproate than mothers taking other antiepileptic drugs.

This medicine has been generally been quite effective in controlling my seizures, once I controlled for other factors like sleep, caffeine, etc.

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Valproate reduces intake of alcoholic beverage among rats: Behavioural Pharmacology Vol 9(8) Dec 1998, 683-689.

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The other difficulty is that it has been shown that patients do not always accurately remember whether any doses were skipped, which can also lead the clinician to believe that the drug regime needs to be altered ().

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Medication status and polycystic ovary syndrome in women with bipolar disorder: A preliminary report: Journal of Clinical Psychiatry Vol 61(3) Mar 2000, 173-178.

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Bialer M, Friedman M, Dubrovsky J, Raz I, Abramsky O ( 1985) Pharmacokinetic evaluation of novel sustained-release dosage forms of valproic acid in humans.

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Adherence to timing of doses proves to be even more critical in once-daily regimes, as variance in the time medication is taken could result in 36 hours with no coverage ().

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Furthermore, within the European Union the granting of a licence for treatment of generalised anxiety disorder requires proof of both acute efficacy and efficacy over the long term, and neither fluoxetine nor sertraline have proved efficacy in prevention of relapse.

Be aware that doctors often use blood tests to check the level of valproic acid in your body.

Lack of effect of mood stabilizers or neuroleptics on GSK-3beta protein levels and GSK-3 activity: International Journal of Neuropsychopharmacology Vol 6(2) Jun 2003, 117-120.

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Figure 2 presents the proportion of patients (X axis) whose percentage reduction from baseline in complex partial seizure rates was at least as great as that indicated on the Y axis in the monotherapy study.

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Serious skin reactions (such as Stevens-Johnson Syndrome and toxic epidermal necrolysis) have been reported with concomitant lamotrigine and valproate administration.

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Admission to psychiatric hospital is usually needed and the onset of alcohol hallucinosis is often an indication for neuroleptic treatment.

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