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How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease.

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We hypothesized that rosuvastatin therapy would improve clinical outcomes in critically ill patients with sepsis-associated ARDS.

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Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor β1-mediated activation of intestinal fibroblasts.

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Translational atherosclerosis research: From experimental models to coronary artery disease in humans.

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CCPA 1935) the court held that the patentee could not use reissue to obtain broader claims to cover “improvements in the art which have occurred since the date of issuance of the original patent” and were “not intended to be incorporated in the original application.

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Risk of thrombocytopenia, which may be more severe than prior to therapy, after discontinuance of eltrombopag.

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However, safety and efficacy have not been established in children younger than 8 years of age.

Only the site pharmacist, pharmacokinetic assay laboratory, coleaders of the coordinating center, and data and safety monitoring board were aware of the study-group assignments.

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Effect of rosuvastatin on concentrations of plasma lipids, urine and plasma oxidative stress markers, and plasma high-sensitivity C-reactive protein in hypercholesterolemic patients with and without type 2 diabetes mellitus: A 12-week, open-label, pilot study.

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The present multicenter, 6-week, randomized, double-blind, parallel-group, clinical trial evaluated the safety and efficacy of ezetimibe (10 mg) added to stable rosuvastatin therapy versus up-titration of rosuvastatin from 5 to 10 mg or from 10 to 20 mg.

Rosuvastatin for Reduction of Myocardial Damage during Coronary Angioplasty - the Remedy Trial.

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Possible side effects of drugs in elderly patients with chronic obstructive pulmonary disease and comorbidity.

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Carbamazepine: May need dose adjustment for APTIOM or carbamazepine.

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Answers B, C, and D may be needed at a later time but are not the most important actions to take first.

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The primary endpoint was hospitalization for acute kidney injury, defined using a validated algorithm (diagnosis code for acute kidney injury in any of the following listed diagnoses: ICD-9 584, 584.

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Statin Medications and Development and Progression of Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms.

Graham urged closer surveillance of the drug to nail down a suspected link between it and kidney failures.

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Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism.

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Is High-Intensity Statin Therapy Associated With Lower Statin Adherence Compared With Low- to Moderate-Intensity Statin Therapy?

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Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.

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Other aspects that may account for differences in outcomes between women and men are related to vascular biological factors such as a smaller atheroma burden and slower progression in women, a smaller vessel size, less collateral flow, lower coronary flow reserve, more vascular stiffness, differences in remodelling, and functional differences of smooth muscle cells in the vessel wall.

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The evidence for treatment, especially with cholesterol-lowering drugs, is much weaker for people who have not yet had the cardiovascular disease described above, known as primary prevention.

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Effect of n-3 polyunsaturated fatty acids and rosuvastatin in patients with heart failure: results of the GISSI-HF trial.

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Statin Therapy and Hemodialysis Vascular Access-Were We Bringing a Knife to a Gunfight and Were Hoping to Win?

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Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS).

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Schering-Plough, Sanofi-Aventis, Isis, Dade Behring, and Vascular Biogenics; and is listed as a coinventor on patents held by Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease, including the use of high-sensitivity C-reactive protein in the evaluation of patients' risk of cardiovascular disease.

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Nevertheless, the newer aspects of the draft guidance seems to have already been implemented at the FDA, as Merck Research Laboratories has already received several specific recommendations from FDA reviewers that referenced the latest draft guidance.

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